ABSTRACT
Background: There are many studies about the association of b fibrinogen gene G-455A polymorphism and the risk of coronary heart disease [CHD]. However, the results of these studies are inconsistent
Objective: This study aimed to investigate the association of b fibrinogen gene G-455A polymorphism with the risk of CHD using meta analysis. This study was limited to the Asian population
Methods: Published studies from PubMed, Embase, and CNKI databases [up to December 20th, 2015] were searched for eligible publications. The following information was extracted from each study: [1] name of first author; [2] year of publication; [3] country of origin; [4] sample size of cases and controls, and [5] size of each allele. The combined odds ratios [ORs] and 95% confidence intervals [95% CIs] for the association between b fibrinogen gene G-455A polymorphism and the risk of CHD were assessed using random or fixed effect model. A comprehensive meta analysis [CMA] 2.0 was used to analyze the data
Results: Nineteen studies [4011 cases/3673 controls] regarding the association of b fibrinogen gene G-455A polymorphism and the risk of CHD were included in this meta analysis. The results indicated that b fibrinogen gene G-455A polymorphism was associated with increased [A vs. G: OR 95% CI= 1.42 [1.19-1.70], p<0.001; AA vs. GG +GA: OR 95% CI= 1.60 [1.13-2.26], p= 0.008; GA vs. GG + AA: OR 95% CI = 1.30 [1.07-1.58], p= 0.008] and decreased the risk of CHD [G vs. A: OR 95% CI= 0.70 [0.59-0.84], p <0.001; GG vs. GA +AA: OR 95% CI= 0.68 [0.55-0.84], p< 0.001]
Conclusions: In the Asian population, the b fibrinogen gene G-455A polymorphism was associated with the risk of CHD